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CAS RN: 58749-22-7 | Product Number: L0261
Licochalcone A
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Purity: >97.0%(HPLC)
Synonyms:
- 4,4'-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone
- (2E)-3-[4-Hydroxy-2-methoxy-5-(2-methyl-3-buten-2-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
53,00 €
|
1 | 25 |
|
| 25MG |
186,00 €
|
1 | 21 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | L0261 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2O__4 = 338.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 58749-22-7 |
| Reaxys Registry Number | 4534154 |
| PubChem Substance ID | 468592138 |
| Merck Index (14) | 5479 |
| MDL Number | MFCD01417903 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
Properties (reference)
| Maximum Absorption Wavelength | 377(EtOH) nm |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | UB8755000 |
Transport Information:
| HS Number | 2914500090 |
Application
Licochalcone A: A Bioactive Flavonoid Contained in Licorice Root
Licorice from roots of plants belonging to the genus Glycyrrhiza (Leguminosae) is an important traditional medicine with its very long history of use. Licochalcone A is a flavonoid contained in licorice root and has a variety of pharmacological effect, including anti-inflammatory and anti-microbial activities.1-3) Recently, more attention has been focused on the application of licochalcone A in cancer chemopreventive therapy. It has been reported that licochalcone A exerts significant antitumor activity in various malignant human cell lines.3-5) (The product is for research purpose only.)
References
- 1) Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects
- 2) Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection
- 3) Natural products in licorice for the therapy of liver diseases: Progress and future opportunities (a review)
- 4) Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells
- 5) Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis
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