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Published TCIMAIL newest issue No.197
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CAS RN: 7724-76-7 | Product Number: I1221
6-(γ,γ-Dimethylallylamino)purine Riboside
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Purity: >97.0%(T)(HPLC)
Synonyms:
- N-(3-Methyl-2-buten-1-yl)adenosine
- N6-Isopentenyladenosine
- 6-(3,3-Dimethylallylamino)-9-(β-D-ribofuranosyl)purine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
€131.00
|
Contact Us | 29 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | I1221 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__2__1N__5O__4 = 335.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 7724-76-7 |
| Reaxys Registry Number | 629507 |
| MDL Number | MFCD00005741 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 144.0 to 148.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 146 °C |
GHS
Related Laws:
| EC Number | 231-771-3 |
| RTECS# | AU7404910 |
Transport Information:
| HS Number | 2934999090 |
Application
N6-Isopentenyladenosine (i6A): A Bioactive Base-Modified Ribonucleoside at a Specific Position of tRNA
N6-Isopentenyladenosine (i6A) is one of the longest known base-modified ribonucleoside and occurs only at a specific position in tRNA found in bacteria and eukaryotes. It has pronounced cytokinin activity in several plant tissues, high anticancer activity in a wide range of cell lines, and exhibits pronounced antiviral activity including SARS-CoV-2.1-4) In addition, the role of N6-isopentenyladenosine in a subset of tRNAs in gene expression has been associated with translational fidelity, translation speed, skewed gene expression, and non-sense suppression.4,5) (The product is for research purpose only.)
References
- 1) N6-Isopentenyladenosine: a potential therapeutic agent for a variety of epithelial cancers
- 2) Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV‑2 Repurposing Potential: In Silico and In Vitro Studies
- 3) Regioselective 1-N-Alkylation and Rearrangement of Adenosine Derivatives
- 4) Biological and pharmacological roles of N6-isopentenyladenosine: an emerging anticancer drug (a review)
- 5) The modified base isopentenyladenosine and its derivatives in tRNA (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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