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Published TCIMAIL newest issue No.197
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CAS RN: 180002-83-9 | Product Number: G0600
GW-405833
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Purity: >97.0%(T)(HPLC)
Synonyms:
- (2,3-Dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]methanone
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
112,00 €
|
1 | 17 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | G0600 |
| Purity / Analysis Method | >97.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__4Cl__2N__2O__3 = 447.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 180002-83-9 |
| Reaxys Registry Number | 7667050 |
| PubChem Substance ID | 468591956 |
| MDL Number | MFCD08061200 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Volumetric Analysis) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 49 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2934999090 |
Application
GW-405833: A Cannabinoid Receptor 2 (CB2) Selective Agonist
Cannabinoids (CBs) are chemical substances that bind to the cannabinoid receptors of the body and brain, and have similar agonistic effects to those produced by the Cannabis Sativa plant. There are two types of cannabinoid receptors, CB1 and CB2. One of them, CB2 receptors are mainly expressed only during active inflammation and do not show undesirable psychotropic or addictive effects. GW-405833 is a selective CB2 receptor agonist, and has been reported to partially reverse the inflammation and hyperalgesia in animal models of acute inflammation.1-4) In addition, the NLRP3 inflammasome inhibitory effect of CB2 receptor selective agonists has recently been attracting attention.5,6) (The product is for research purpose only.)
References
- 1) Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia, and catalepsy
- 2) A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
- 3) Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833
- 4) The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress
- 5) NLRP3 inflammasome and its inhibitors: a review
- 6) Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective (a review)
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