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Published TCIMAIL newest issue No.197
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CAS RN: 143485-51-2 | Product Number: E1357
Eltoprazine Dihydrochloride
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine Dihydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
110,00 €
|
Contact Us | ≥40 |
|
| 50MG |
365,00 €
|
Contact Us | 39 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1357 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__6N__2O__2·2HCl = 293.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 143485-51-2 |
| PubChem Substance ID | 468591727 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 257 °C(dec.) |
GHS
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
Eltoprazine Dihydrochloride: A Small Molecule 5HT1A/1B Partial Agonist
Eltoprazine dihydrochloride is a small molecule 5HT1A/1B partial agonist. In clinical, it has been used as an antiaggressive agent (serenic) for the treatment of adult attention deficit hyperactivity disorder (ADHD) and Alzheimer’s aggression. Recently, it approved by the Food and Drug Administration (FDA) as an orphan drug for the treatment of Parkinson’s disease levodopa-induced dyskinesia (PD-LID). (The product is for research purpose only.)
References
- 1) Postsynaptic 5-HT1 receptors and offensive aggression in rats: a combined behavioral and autoradiographic study with eltoprazine
- 2) Behavioural pharmacology of the serenic, eltoprazine (a review)
- 3) Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine receptors: a comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635
- 4) Study of the antidyskinetic effect of eltoprazine in animal models of levodopa-induced dyskinesia
- 5) Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease: a dose-finding study
- 6) Serotonergic Approaches in Parkinson's Disease: Translational Perspectives, an Update (a review)
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