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Published TCIMAIL newest issue No.197
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CAS RN: 251456-60-7 | Product Number: D4188
4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
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![4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide")
Purity: >97.0%(HPLC)
Synonyms:
- M 344
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€149.00
|
1 | 23 |
|
| 100MG |
€518.00
|
Contact Us | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4188 |
| Purity / Analysis Method | >97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__5N__3O__3 = 307.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 251456-60-7 |
| Reaxys Registry Number | 8570090 |
| PubChem Substance ID | 160871269 |
| MDL Number | MFCD03453554 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Elemental analysis(Nitrogen) | 13.20 to 13.80 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 152 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2928009090 |
Application
M344: A Histone Deacetylase (HDAC) Inhibitor
Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents with potential for disruption of critical cellular processes in cancer cells. M344 is a synthesized HDAC inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in cancer cells. (The product is for research purpose only.)
References
- Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
- Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation
- The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells
- M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells
- Histone deacetylase inhibitor M344 inhibits cell proliferation and induces apoptosis in human THP-1 leukemia cells
- Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB
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