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Published TCIMAIL newest issue No.197
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CAS RN: 38819-10-2 | Product Number: A2739
9-β-D-Arabinofuranosylguanine
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Purity: >98.0%(HPLC)
Synonyms:
- Ara-G
- Guanine 9-β-D-Arabinofuranoside
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€16.00
|
1 | ≥40 |
|
| 50MG |
€37.00
|
1 | 11 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | A2739 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__0H__1__3N__5O__5 = 283.24 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 38819-10-2 |
| Reaxys Registry Number | 1225954 |
| PubChem Substance ID | 253662300 |
| MDL Number | MFCD00065486 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 24.00% to 25.50% (calcd.on anh.substance) |
| Water | 4.0 to 7.0 % |
Properties (reference)
| Melting Point | 225 °C |
| Maximum Absorption Wavelength | 252 nm |
GHS
Related Laws:
| RTECS# | MF8301000 |
Transport Information:
| HS Number | 2934999090 |
Application
Ara-G: An Inhibitor of DNA Replication in T-Leukemic Cells
Arabinosylguanine (ara-G) is triphosphorylated by multiple kinases intracellularly to the active nucleotide, ara-GTP, which inhibits the DNA replication in T-leukemic cells. Ara-G is used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LBL). From the 2000s, nelarabine (the 6-methoxy pro-drug of ara-G) have been introduced and used for the treatment of T-All and T-LBL. In organic synthesis, ara-G is used as an intermediate for the synthesis of guanosine analogs. (The product is for research purpose only.)
References
- Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells
- Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts
- Transport and metabolism of 9-β-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx
- Nelarabine in the treatment of refractory T-cell malignancies (a review)
- Synthesis of 2'-iodo- and 2'-bromo-ATP and GTP analogs as potential phasing tools for X-ray crystallography
- Synthesis, Oxidation Behavior, Crystallization and Structure of 2'-Methylseleno Guanosine Containing RNAs
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