Modulators of the JNK Signaling Pathway

The JNK signal pathway, a member of the mitogen-activated protein kinase (MAPK) family, is known to be activated by growth factors, cytokines and environmental stress.¹⁾ Various biological functions – such as apoptosis, cell migration – are known to be modulated by activation of the JNK signaling pathway, selective inhibition of JNK can inhibit the proliferation and metastasis of cancer cells.²⁾ Thus, its inhibitors are commonly used in cancer research.
TCI sells SP 600125 (1) and SU 3327 (2), selective inhibitors targeting kinases involved in this pathway at a special [Optimized for Cell Culture] grade.

About [Optimized for Cell Culture]
The [Optimized for Cell Culture] series comprises products that have undergone mycoplasma and endotoxin testing, ensuring their safety for use in cell biology research. These products are ideal for various applications, including disease modeling and regenerative medicine research.

References

• 1) Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
  • Q. Wu, W. Wu, V. Jacevic, T. C. C. Franca, X. Wang, K. Kuca, J. Enzyme Inhib. Med. Chem. 2020, 35, 574.
• 2) JNK Pathway Signaling: A Novel and Smarter Therapeutic Target for Various Biological Diseases
  • A. Kumar, U. K. Singh, S. G. Kini, V. Garg, S. Agrawal, P. K. Tomar, P. Pathak, A. Chaudhary, P. Gupta, A. Malik, Future Med. Chem. 2015, 7, 2065.

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