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Non-detergent Sulfobetaines
No.166(July 2015)
Non-detergent sulfobetains (NDSBs) have been utilized for solubilization and crystallization of proteins.1,2) In addition, NDSBs have been employed to prevent protein aggregation and to renature denatured protein.3,4) These sulfobetaine compounds are zwitterionic compounds.1,3) Compounds, 1~3, shown here are frequently-used NDSBs.
References
- 1)Non-detergent sulfobetaines: A new class of mild solubilization agents for protein purification
- 2)A new additive for protein crystallization
- 3)Physical–chemical features of non-detergent sulfobetaines active as protein-folding helpers
- 4)Non-detergent sulphobetaines: A new class of molecules that facilitate in vitro protein renaturation
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