Published TCIMAIL newest issue No.197
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Phosphatidylinositol 3-Kinase Inhibitor
No.164(January 2015)
PKB/Akt, a serine/threonine kinase, regulates many kinds of important cellular functions including metabolism, proliferation, survival, apoptosis, etc.1) The kinase is activated by phosphatidylinositol 3-kinase (PI3-k) pathway.1)
LY294002 (1) is a specific inhibitor of PI3-k.2) 1 blocks the PI3-k/Akt pathway inducing apoptosis in many types of tumor cells.3) 1 also suppresses self-renewal4) and proliferation5) of embryonic stem cells and enhances the generation of mouse induced pluripotent stem (iPS) cells.6)
References
- 1)PI3K-PKB/Akt pathway
- 2)A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
- 3)LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway
- 4)Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling
- 5)Phosphoinositide 3-kinase inhibitor LY294002 but not serum withdrawal suppresses proliferation of murine embryonic stem cells
- 6)Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
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