Published TCIMAIL newest issue No.196
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Globo-series Glycosphingolipids
Glycosphingolipids are expressed tissue-specifically and play important roles in cellular processes such as proliferation, migration, senescence, apoptosis and endocytosis. Globo-series glycolipids also have various biological functions, such as O157 Escherichia coli bacterial toxin receptor [Gb3], breast cancer marker [Globo-H], and early embryo-specific antigen‡ [Gb5 (SSEA-3)/Sialyl Gb5 (SSEA-4)]. In addition, globo-series glycolipids are present in human erythrocytes and are antigens of a very rare blood group called P1PK. TCI has a lineup of a variety of globo-series oligosaccharides prepared by chemical synthesis.
‡Early embryo-specific antigen is also called Stage-Specific Embryonic Antigen (SSEA). Glycan structure changes according to the stage of cell differentiation. Therefore, it is used as a marker for iPS cells and human ES cells.1)
Relationship between Globo-series Oligosaccarides and Cancer
The globo-series glycosphingolipids include Gb5 (SSEA-3) and Globo H, which play a role in immune suppression and angiogenesis making them targets for potential new therapies.2,3)
Related Products
Gb3-related Products
- M1767
- Gb3-β-MP
- G0402
- Gb3-β-ethylamine
- G0403
- Gb3-β-ethylazide
- G0479
- Globotriose
- H1718
- HSA-Gb3
- A2506
- Anti-Gb3 Monoclonal Antibody
- A2822
- Anti-Gb3 Monoclonal Antibody Biotin Conjugate
- (* A2506 and A2822 are unavailable in China.)
Gb4-related Products
Forssman-related Products
Gb5 (SSEA-3)-related Products
SialylGb5(SSEA-4)-related Products
Globo-H-related Products
References
- 1) Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage-Specific Embryonic Antigens
- 2) The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets
- 3) Recent advances and future perspectives on carbohydrate-based cancer vaccines and therapeutics
