2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine

References

• Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
  • T. H. Marsilje, W. Pei, B. Chen, W. Lu, T. Uno, Y. Jin, T. Jiang, S. Kim, N. Li, M. Warmuth, Y. Sarkisova, F. Sun, A. Steffy, A. C. Pferdekamper, A. G. Li, S. B. Joseph, Y. Kim, B. Liu, T. Tuntland, X. Cui, N. S. Gray, R. Steensma, Y. Wan, J. Jiang, G. Chopiuk, J. Li, W. P. Gordon, W. Richmond, K. Johnson, J. Chang, T. Groessl, Y.-Q. He, A. Phimister, A. Aycinena, C. C. Lee, B. Bursulaya, D. S. Karanewsky, H. M. Seidel, J. L. Harris, P.-Y. Michellys, J. Med. Chem. 2013, 56, 5675.
• Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
  • Z. Liu, J. Ai, X. Peng, Z. Song, K. Wu, J. Zhang, Q. Yao, Y. Chen, Y. Ji, Y. Yang, M. Geng, A. Zhang, ACS Med. Chem. Lett. 2014, 5, 304.
• Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor
  • G. A. Kang, M. Lee, D. Song, H. K. Lee, S. Ahn, C. H. Park, C. O. Lee, C. S. Yun, H. Jung, P. Kim, J. D. Ha, S. Y. Cho, H. R. Kim, J. Y. Hwang, Bioorg. Med. Chem. Lett. 2015, 25, 3992.
• Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases
  • Z. Song, Y. Yang, Z. Liu, X. Peng, J. Guo, X. Yang, K. Wu, J. Ai, J. Ding, M. Geng, A. Zhang, J. Med. Chem. 2015, 58, 197.