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Published TCIMAIL newest issue No.197
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CAS RN: 85622-93-1 | Product Number: T2744
Temozolomide
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Purity: >98.0%(HPLC)
Synonyms:
- 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 500MG |
€23.00
|
7 | ≥100 |
|
| 5G |
€143.00
|
4 | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T2744 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__6H__6N__6O__2 = 194.15 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 85622-93-1 |
| Reaxys Registry Number | 5547136 |
| PubChem Substance ID | 125307782 |
| Merck Index (14) | 9139 |
| MDL Number | MFCD00866492 |
Specifications
| Appearance | White to Light yellow to Light red powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 206 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | NJ5927050 |
Transport Information:
| HS Number | 2933998090 |
Application
Studies of the Antitumor Activity of Temozolomide
References
- Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials
- Temozolomide and treatment of malignant glioma
- H. S. Friedman, T. Kerby, H. Calvert, Clin. Cancer Res. 2000, 6, 2585.
- Marked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedules
- CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
- Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
- Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine
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Articles/Brochures
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