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CAS RN: 171599-83-0 | Product Number: S0986
Sildenafil Citrate
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Purity: >98.0%(HPLC)
Synonyms:
- 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine Citrate
- 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one Citrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€16.00
|
1 | 29 |
|
| 100MG |
€40.00
|
2 | 16 |
|
| 1G |
€281.00
|
1 | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0986 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__3__0N__6O__4S·C__6H__8O__7 = 666.70 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image), 25MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 171599-83-0 |
| Related CAS RN | 139755-83-2 |
| Reaxys Registry Number | 9035645 |
| PubChem Substance ID | 354333548 |
| Merck Index (14) | 8489 |
| MDL Number | MFCD09026931 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
Properties (reference)
| Melting Point | 192 °C(dec.) |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P260 : Do not breathe dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | TL4284390 |
Transport Information:
| HS Number | 2935909099 |
Application
Sildenafil Citrate: A cGMP – Specific PDE5 Inhibitor
Sildenafil citrate is a selective inhibitor of cyclic guanosine monophosphate (cGMP) - specific phosphodiesterase type 5 (PDE5) which is the predominant PDE isoenzyme in human corpora cavernosa. In there, nitric oxide (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP. Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP in the corpus cavernosum. Recently, sildenafil citrate has been indicated for the treatment of pulmonary arterial hypertension and Alzheimer's disease et al.For reference, we also have related compounds/synthetic intermediates [E1134] [M2773] of sildenafil. (The product is for research purpose only.)
References
- Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isoenzymes
- Cyclic GMP phosphodiesterase-5: Target of sildenafil (a review)
- Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man
- Sildenafil citrate therapy for pulmonary arterial hypertension
- Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-β load in an Alzheimer's disease mouse model
- Versatile effects of sildenafil: recent pharmacological applications (a review)
PubMed Literature
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