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Published TCIMAIL newest issue No.197
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CAS RN: 17388-39-5 | Product Number: S0897
Swertiamarin
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€109.00
|
Contact Us | Contact Us |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0897 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__2O__1__0 = 374.34 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 17388-39-5 |
| Reaxys Registry Number | 55278 |
| PubChem Substance ID | 172088922 |
| Merck Index (14) | 9010 |
| MDL Number | MFCD07783984 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -136 to -141 deg(C=0.5、EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 114 °C |
| Specific Rotation | -138° (C=0.5,EtOH) |
| Maximum Absorption Wavelength | 238(MeOH) nm |
GHS
Related Laws:
| RTECS# | UQ1366700 |
Transport Information:
| HS Number | 2938909090 |
Application
Swertiamarin: The Bitter Component of the Herb of Swertia japonica
Swertiamarin, a secoiridoid glycoside, is the bitter component of the herb of Swertia japonica.1) The main biosynthetic pathway of swertiamarin in the Gentianae is a route which leads from iridodial via deoxyloganic acid or loganic acid to secoiridoids.2) It has been reported that swertiamarin has diverse biological activities, including anti-inflammatory,3) anti-hyperlipidaemic,3) anti-nociceptive,4) hepatoprotective,4) anti-diabetic5-7) and antioxidant7) effects. (The product is for research purpose only)
References
- 1) Systematic review on xanthones and others isolates from genus Swertia
- A. Jamwal, Int. J. Pharm. Chem. Sci. 2012, 1, 1115.
- 2) Chemotaxonomy and pharmacology of Gentianaceae
- S. R. Jensen, J. Schripsema, in Gentianaceae: Systematics and Natural History, eds. by L. Struwe, V. A. Albert, Cambridge University Press, Cambridge, 2002, pp. 573-631.
- 3) Naturally occurring iridoids, secoiridoids and their bioactivity. An updated review, part 3
- 4) Naturally occurring iridoids, secoiridoids. An updated review, part 4
- 5) Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin
- 6) Glycogen phosphorylase-a is a common target for anti-diabetic effect of iridoid and secoiridoid glycosides
- 7) A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases
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