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Published TCIMAIL newest issue No.197
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CAS RN: 6591-63-5 | Product Number: Q0010
Quinidine Sulfate Dihydrate
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Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€38.00
|
1 | ≥100 |
|
| 25G |
€120.00
|
2 | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | Q0010 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__4__0H__4__8N__4O__4·H__2SO__4·2H__2O = 782.95 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 6591-63-5 |
| PubChem Substance ID | 87575548 |
| Merck Index (14) | 8060 |
| MDL Number | MFCD00135926 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 80.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +268 to +280 deg(C=2, 0.1mol/L HCl) |
| Water | 4.0 to 5.0 % |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | 275° (C=2,0.1mol/L HCl) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | VA5605000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2939200000 |
Application
Quinidine Sulfate: A Class 1a Antiarrhythmic Agent
Quinidine [Q0006], a cinchona alkaloid, originally derived from the bark of the Cinchona tree. Quinidine is a class 1a antiarrhythmic agent which interferes both with the sodium (Na+) and potassium (K+) channels, with a pharmacological profile of action similar to that of disopyramide [D2793]. Quinidine inhibits the fast inward sodium current, and depresses the conduction velocity. Consequently, quinidine decreases myocardial excitability. Its sulfate is used clinically. (The product is for research purpose only.)
References
- Quinidine (a review)
- Quinidine revisited (a review)
- Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs (a review)
- Quinidine sulfate (a review on the nomenclature, physical properties, synthesis, biosynthesis, metabolism and pharmacokinetics and determination)
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