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CAS RN: 61825-94-3 | Product Number: O0372

Oxaliplatin


Purity:
Synonyms:
  • (trans-1,2-Cyclohexanediamine)oxalatoplatinum(II)
Product Documents:
100MG
€128.00
1   ≥100 

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Product Number O0372
Molecular Formula / Molecular Weight C__8H__1__4N__2O__4Pt = 397.29 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive,Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image)
CAS RN 61825-94-3
Reaxys Registry Number 14621501
PubChem Substance ID 125309438
Merck Index (14) 6912
MDL Number

MFCD00866327

Specifications
Appearance White to Almost white powder to crystal
Elemental analysis(Nitrogen) 6.70 to 7.40 %
NMR confirm to structure
Properties (reference)
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
H341 : Suspected of causing genetic defects.
Precautionary Statements P261 : Avoid breathing dust.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Related Laws:
RTECS# TP2275850
Transport Information:
HS Number 2843909000
Application
Platinum Coordination Complexes as Antitumor Agents

O0372

The development of platinum coordination complexes as antitumor agents began in the 1960s, and the highest antitumor activity was exhibited by cisplatin [D3371], approved by FDA in 1978. Improved versions carboplatin [C2043] and oxaliplatin were developed to avoid the serious side effects and the problem with resistance associated with the use of cisplatin.1-5)
The platinum complexes diffuse to the tumor cell, where they undergo hydrolysis displacement of their one chloride or carboxylate group leading to a platinum cation. The resulting cation coordinates to the guanine N7-position of DNA give a coordination cation. Then, intrastrand cross-linking occurs to anther guanine via further hydrolysis displacement of the remaining chloride or carboxylate. The forming [Pt(NH2R)2]2+ ― DNA complex distort the DNA helix (Fig. 1 and 2)6). Thus, DNA duplication is hindered, which ultimately triggers tumor cell apoptosis.3)

References


Application
Reagent for pain model

References


Application
Pharmacology study

References


PubMed Literature


TCIMAIL
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