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CAS RN: 74050-98-9 | Product Number: K0051
Ketanserin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€36.00
|
1 | 9 |
|
| 1G |
€137.00
|
1 | 5 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | K0051 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__2FN__3O__3 = 395.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 74050-98-9 |
| Reaxys Registry Number | 4913068 |
| PubChem Substance ID | 253661148 |
| Merck Index (14) | 5296 |
| MDL Number | MFCD00083392 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 231.0 to 235.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 233 °C |
| Solubility in water | Insoluble |
| Degree of solubility in water | 10 mg/l |
| Solubility (slightly sol. in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 277-680-2 |
| RTECS# | VA1411190 |
Transport Information:
| HS Number | 2933998090 |
Application
Ketanserin: A Selective 5-HT2a Receptor Antagonist with Weak α1-Adrenoceptor Antagonistic Activity
Ketanserin is a selective 5-HT2a receptor antagonist. 5-HT receptors can be divided into some receptor subtypes. Ketanserin is used for discrimination between 5-HT receptor subtypes. Ketanserin also has weak α1-adrenoceptor antagonistic activity which may explain its antihypertensive mechanism of action. Ketanserin inhibits the effects of serotonin on platelets, and inhibits vasoconstriction caused by the catecholamine. (The product is for research purpose only.)
References
- Ketanserin: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease
- Ketanserin and ritanserin discriminate between recombinant human 5-HT1Dα and 5-HT1Dβ receptor subtypes
- Molecular modeling of serotonin, ketanserin, ritanserin and their 5-HT2C receptor interactions
- Ketanserin and spiperone as templates for novel serotonin 5-HT2A antagonists (a review)
- Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin (a review)
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