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Published TCIMAIL newest issue No.197
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CAS RN: 50-91-9 | Product Number: D2235
2'-Deoxy-5-fluorouridine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
- 5-Fluoro-2'-deoxy-β-uridine
- Floxuridine
- FUDR
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 100MG |
€30.00
|
1 | 24 |
|
| 500MG |
€103.00
|
1 | ≥40 |
|
| 1G |
€180.00
|
Contact Us | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D2235 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__1FN__2O__5 = 246.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50-91-9 |
| Reaxys Registry Number | 90221 |
| PubChem Substance ID | 87568673 |
| SDBS (AIST Spectral DB) | 19323 |
| Merck Index (14) | 4112 |
| MDL Number | MFCD00006530 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 148.0 to 152.0 °C |
Properties (reference)
| Melting Point | 150 °C |
| Specific Rotation | 38° (C=1,H2O) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol, Acetone |
| Solubility (insoluble in) | Ether, Benzene, Chloroform |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| EC Number | 200-072-5 |
| RTECS# | YU7525000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2934999090 |
Application
Floxuridine: An Antitumor Antimetabolite with Inhibition of Thymidylate Synthase
Floxuridine (FUDR), an antitumor antimetabolite, is a prodrug of 5-fluorouracil (5-FU) [F0151]. Floxuridine is rapidly catabolized to 5-FU in vivo. Similarly to 5-FU, floxuridine inhibits thymidilate synthetase (TS) which is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). dTMP forms thymidine, a nucleic acid in deoxyribonucleic acid (DNA). Therefore, the primary effect of floxuridine is to interfere with the synthesis of DNA. (The product is for research purpose only.)
References
- Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine
- Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors (a review)
- Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer (a review)
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