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Published TCIMAIL newest issue No.197
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CAS RN: 305-03-3 | Product Number: C2939
Chlorambucil
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Purity: >98.0%(GC)(T)
Synonyms:
- 4-[4-[Bis(2-chloroethyl)amino]phenyl]butyric Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
€50.00
|
1 | 9 |
|
| 1G |
€210.00
|
Contact Us | 23 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C2939 |
| Purity / Analysis Method | >98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__1__4H__1__9Cl__2NO__2 = 304.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 305-03-3 |
| Reaxys Registry Number | 999011 |
| PubChem Substance ID | 253662017 |
| Merck Index (14) | 2073 |
| MDL Number | MFCD00021783 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 65.0 to 69.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 67 °C |
| Maximum Absorption Wavelength | 588(DMSO aq.) nm |
| Degree of solubility in water | 7.5 g/l 25 °C |
| Solubility (soluble in) | Benzene, Ether |
| Solubility (slightly sol. in) | Acetone, Chloroform, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H370 : Causes damage to organs. H372 : Causes damage to organs through prolonged or repeated exposure. H341 : Suspected of causing genetic defects. H350 : May cause cancer. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 206-162-0 |
| RTECS# | ES7525000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2922498590 |
Application
Chlorambucil: A Nitrogen Mustard Type Antitumor Alkylating Agent
Chlorambucil, a nitrogen mustard type antitumor alkylating agent, generates covalent adducts with double-helical DNA and inhibits cell proliferation. Chlorambucil has been shown to be an effective single-agent treatment in chronic lymphocytic leukemia (CLL), and to be useful as part of combination chemotherapy in non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL) and Waldenstrom's macroglobulinemia. (The product is for research purpose only.)
References
- The cytotoxicity, DNA crosslinking ability and DNA sequence selectivity of the aniline mustards melphalan, chlorambucil and 4-[bis(2-chloroethyl)amino]benzoic acid
- Chlorambucil in chronic lymphocytic leukemia: Mechanism of action (a review)
- Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair (a review)
- Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia (a review)
- Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand
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