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Published TCIMAIL newest issue No.197
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CAS RN: 118-10-5 | Product Number: C0350
Cinchonine
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Purity: >98.0%(T)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€38.00
|
5 | ≥60 |
|
| 200G |
€273.00
|
2 | 36 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | C0350 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__9H__2__2N__2O = 294.40 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 118-10-5 |
| Reaxys Registry Number | 89689 |
| PubChem Substance ID | 87565483 |
| SDBS (AIST Spectral DB) | 15239 |
| Merck Index (14) | 2287 |
| MDL Number | MFCD00064372 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 80.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +218.0 to +228.0 deg(C=0.5, EtOH) |
Properties (reference)
| Melting Point | 261 °C |
| Specific Rotation | 223° (C=0.5,EtOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Alcohol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 204-234-6 |
| RTECS# | GD3500000 |
Transport Information:
| HS Number | 2939200000 |
Application
Cinchonine: A Cinchona Alkaloid with both Biological and Asymmetric Catalytic Activity
Cinchona alkaloids (quinine [Q0028], quinidine [Q0006], cinchonidine [C0347] and cinchonine) is isolated from Cinchona plants, and have been used as traditional medicines for the treatment of malaria as well as several diseases.1) Recently studies has revealed that cinchona alkaloids exerts antimalarial, anti-obesity, anti-cancer, anti-oxidant, anti-inflammatory, anti-microbial activity.2,3) On the other hand, in organic chemistry, cinchona alkaloids have been used as useful catalysts in asymmetric synthesis.3-5) (The product is for research purpose only.)
References
- 1) Quantitative determination of major alkaloids in Cinchona bark by supercritical fluid chromatography
- 2) Spectrum of biological properties of cinchona alkaloids: a brief review
- 3) Alkaloid group of Cinchona officinalis: structural, synthetic, and medicinal aspects (a review)
- 4) Organic chemistry of Cinchona alkaloids (a review)
- 5) Cinchonine and thiourea (a review)
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