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CAS RN: 55079-83-9 | Product Number: A3097
Acitretin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
108,00 €
|
1 | 21 |
|
| 250MG |
350,00 €
|
2 | 38 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3097 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__6O__3 = 326.44 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 55079-83-9 |
| Reaxys Registry Number | 2158933 |
| PubChem Substance ID | 354335416 |
| Merck Index (14) | 112 |
| MDL Number | MFCD00866632 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 230 °C |
| Maximum Absorption Wavelength | 352(MeOH) nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
| EC Number | 259-474-4 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| HS Number | 2918999090 |
Application
Acitretin: A Retinoic Acid Derivative that is an Active Metabolite of Etretinate
Acitretin is a retinoic acid (vitamin A acid) [R0064] derivative that is the major active metabolite of etretinate [E1293]. Acitretin s used for the treatment of severe psoriasis and other dyskeratoses, but the precise mechanism of action of it is not fully understood. However, the pharmacological profile of acitretin suggests that it acts by normalizing pathological changes in epidermal and dermal skin, particularly inhibiting hyperkeratinization and cell differentiation. In addition, acitretin reportedly has teratogenic potential. (The product is for research purpose only.)
References
- Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro
- Acitretin: a review of its pharmacology and therapeutic use
- Systemic retinoids in chemoprevention of non-melanoma skin cancer (a review)
- Acitretin in dermatology: a review
- Comparative teratogenicity of nine retinoids in the rat
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