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CAS RN: 102121-60-8 | Product Number: A3082
AM580
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Purity: >98.0%(HPLC)
Synonyms:
- CD336
- 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5MG |
€60.00
|
1 | 21 |
|
| 25MG |
€194.00
|
2 | 3 |
|
| 100MG |
€525.00
|
2 | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A3082 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__2__5NO__3 = 351.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 102121-60-8 |
| Reaxys Registry Number | 3565084 |
| PubChem Substance ID | 468590144 |
| MDL Number | MFCD00673916 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
Properties (reference)
| Melting Point | 260 °C |
| Maximum Absorption Wavelength | 283(EtOH(95vol%)) nm |
GHS
Related Laws:
| RTECS# | DH6834890 |
Transport Information:
| HS Number | 2924297099 |
Application
AM580: A Retinoic Acid Receptor-α (RARα)-Selective Agonist
AM580, a stable retinobenzoic acid derivative, is a retinoic acid receptor-α (RARα)-selective agonist. Retinoids regulate a wide variety of essential biological processes. RARα is a member of retinoic acid receptors (RARs) which act as ligand-activated transcription factors controlling the expression of a number of target genes. It is reported that AM580 promotes the reprogramming of somatic cells to induced pluripotent stem cells and inhibits tumor cell proliferation. (The product is for research purpose only.)
References
- AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells
- Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity
- The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
- Novel non-carboxylic acid retinoids: 1,2,4-Oxadiazol-5-one derivatives
- Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1
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