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Published TCIMAIL newest issue No.197
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CAS RN: 497-76-7 | Product Number: A0522
Arbutin
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Purity: >95.0%(HPLC)
Synonyms:
- Hydroquinone-β-D-glucoside
- 4-Hydroxyphenyl β-D-Glucopyranoside
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
27,00 €
|
6 | ≥40 |
|
| 25G |
106,00 €
|
7 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A0522 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__6O__7 = 272.25 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 497-76-7 |
| Reaxys Registry Number | 89673 |
| PubChem Substance ID | 87562130 |
| SDBS (AIST Spectral DB) | 10908 |
| Merck Index (14) | 773 |
| MDL Number | MFCD00016915 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 197.0 to 202.0 °C |
| Specific rotation [a]20/D | -63.0 to -68.0 deg(C=4, H2O)(calcd.on anh.substance) |
| Solubility in Water | very faint turbidity |
| Water | max. 3.0 % |
Properties (reference)
| Melting Point | 198 °C |
| Specific Rotation | -65.5° (C=4,H2O) |
| Solubility in water | Soluble |
| Solubility (soluble in) | Alcohol |
GHS
Related Laws:
| EC Number | 207-850-3 |
| RTECS# | CE8863000 |
Transport Information:
| HS Number | 2938909090 |
Application
Arbutin: A Competitive Inhibitor of Tyrosinase
Arbutin (β-arbutin) is a hydroquinone glycoside, which is accumulated in many plant species such as bearberry (Arctostaphylos uva-ursi L.), bergenia (Bergenia spp.) and myrothamnus (Myrothamnus flabellifolia Welw.). It has been reported that arbutine inhibits the oxidation of L-tyrosine in a competitive manner catalyzed by tyrosinase which is an oxidase that catalyzes the rate-limiting step in melanin (a group of natural pigments) biosynthesis. Arbutins (α- and β-arbutins) are widely used in the cosmetic industry. (Related product: α-arbutin [A3284]) (The product is for research purpose only.)
References
- Arbutin: mechanism of its depigmenting action in human melanocyte culture
- Effects of α- and β-arbutin on activity of tyrosinases from mushroom and mouse melanoma
- Survey and mechanism of skin depigmenting and lightening agents (a review)
- Biotechnological production of arbutins (α- and β-arbutins), skin-lightening agents, and their derivatives (a review)
- Analyses of arbutin and chlorogenic acid, the major phenolic constituents in Oriental pear
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