Cobalt Complexes to Catalyze the Dehydrogenative Cross-Coupling Reactions

Co(dmgH)₂(DMAP)Cl (1) and Co(dmgH)₂PyCl (2) are utilized as catalysts for the oxidant-free dehydrogenative cross-coupling reactions and dehydrogenation reactions of nitrogen-containing heterocyclic rings. For instance, in the presence of 1 and a photoredox catalyst, cyclohexanones react with amines to give the corresponding aniline derivatives via C-N bond formation at the ketone moiety and successive aromatization of the cyclohexane ring. This reaction has the great advantage of not using any oxidants. In addition, the dehydrogenation of nitrogen-containing heterocycles proceeds under similar conditions to give aromatized heterocycles.

References

• 1) A photochemical dehydrogenative strategy for aniline synthesis
  • S. Dighe, F. Juliá, A. Luridiana, J. J. Douglas, D. Leonori, Nature 2020, 584, 75.
• 2) Acceptorless Dehydrogenation of N-Heterocycles by Merging Visible-Light Photoredox Catalysis and Cobalt Catalysis
  • K.-H. He, F.-F. Tan, C.-Z. Zhou, G.-J. Zhou, X.-L. Yang, Y. Li, Angew. Chem. Int. Ed. 2017, 56, 3080.

Related Compounds

D5924

Co(dmgH)₂Cl₂

D4887

Ir[(ppy)₂(dtbbpy)]PF₆

D0134

1,4-Diazabicyclo[2.2.2]octane (= DABCO)

T1655

Ru(bpy)₃Cl₂·6H₂O

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