Chiral Ruthenium Complex for Enantioselective Cyclopropanations
Ru(II)-(S)-Pheox Catalyst (1) is a chiral phenyloxazoline-ruthenium(II) complex, developed by Iwasa et al.
1 catalyzes highly enantioselective cyclopropanation of various olefins using diazoacetates1-6,8) or diazomethylphosphonates.7,8) In addition, 1 is also used for an enantioselective Si–H insertion reaction of α-diazo esters.9) 1 is a promising reagent for the synthesis of medicinally relevant optically active cyclopropane derivatives.
References
- 1)A.-M. Abu-Elfotoh, K. Phomkeona, K. Shibatomi, S. Iwasa, Angew. Chem. Int. Ed. 2010, 49, 8439.
- 2)S. Chanthamath, K. Phomkeona, K. Shibatomi, S. Iwasa, Chem. Commun. 2012, 48, 7750.
- 3)S. Chanthamath, D. T. Nguyen, K. Shibatomi, S. Iwasa, Org. Lett. 2013, 15, 772.
- 4)S. Chanthamath, D. S. Takaki, K. Shibatomi, S. Iwasa, Angew. Chem. Int. Ed. 2013, 52, 5818.
- 5)S. Chanthamath, H. W. Chua, S. Kimura, K. Shibatomi, S. Iwasa, Org. Lett. 2014, 16, 3408.
- 6)Y. Nakagawa, S. Chanthamath, K. Shibatomi, S. Iwasa, Org. Lett. 2015, 17, 2792.
- 7)S. Chanthamath, S. Ozaki, K. Shibatomi, S. Iwasa, Org. Lett. 2014, 16, 3012.
- 8)S. Chanthamath, S. Iwasa, Acc. Chem. Res. 2016, 46, 2080.
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