轻松扫码查看产品文档 | TCIMAIL No.197 已上新 | TCI试剂——品质可靠，值得信赖
订购方法？联系方式：021-67121386 / Sales-CN@TCIchemicals.com
Maximum quantity allowed is 999
请选择数量
Protein Kinase Inhibitor
No.171(October 2016)
Isoquinolinesulfonamide derivatives have been developed as protein kinase inhibitors.1) Fasudil hydrochloride (1) is one of the derivatives and inhibits various protein kinases (an example; Tables 1).1-3)
Human embryonic stem (hES) cells are vulnerable to apoptosis upon cellular detachment or dissociation and the cloning efficiency of dissociated hES cells is generally low, for example 0.24~0.83%4) and 0.4%.5) Treatment of hES cells with 1 diminishes the cell-dissociation-induced apoptosis, resulting in the promotion of colony formation by undifferentiated cells (Table 2).6)
References
- 1)Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
- 2)Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells
- 3)Specificity and mechanism of action of some commonly used protein kinase inhibitors
- 4)Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
- 5)Neurotrophins mediate human embryonic stem cell survival
- 6)A ROCK inhibitor permits survival of dissociated human embryonic stem cells
The prices are subject to change without notice. Please confirm the newest price by our online catalog before placing an order.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.
In addition, sales products changes with areas. Please understand that a product is not available when the product details page is not displayed.