Glycogen Synthase Kinase (GSK) Inhibitor

References

• 1)GSK-3-selective inhibitors derived from Tyrian purple indirubins
  • L. Meijer, A.-L. Skaltsounis, P. Magiatis, P. Polychronopoulos, M. Knockaert, M. Leost, X. P. Ryan, C. A. Vonica, A. Brivanlou, R. Dajani, C. Crovace, C. Tarricone, A. Musacchio, S. M. Roe, L. Pearl, P. Greengard, Chem. Biol. 2003, 10, 1255.
• 2)Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
  • P. Polychronopoulos, P. Magiatis, A.-L. Skaltsounis, V. Myrianthopoulos, E. Mikros, A. Tarricone, A. Musacchio, S. M. Roe, L. Pearl, M. Leost, P. Greengard, L. Meijer, J. Med. Chem. 2004, 47, 935.
• 3)Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
  • N. Sato, L. Meijer, L. Skaltsounis, P. Greengard, A. H. Brivanlou, Nat. Med. 2004, 10, 55.
• 4)The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes
  • A.-S. Tseng, F. B. Engel, M. T. Keating, Chem. Biol. 2006, 13, 957.

Page Top