Cell Differentiation Research Reagent

No.162(July 2014)

M2373: Myoseverin (1)

Myoseverin (1), one of the 2,6,9-trisubstituted purine derivatives, is a microtubule-binding molecule and inhibits tubulin polymerization.¹⁾ 1 induces fragmentation of multinucleated myotubes into mononucleated cells.^1,2) It was reported that the derived cells retain the properties of parental myotubes, ²⁾ and the capability to revert to multinucleated tubes after treatment.³⁾

References

1)Myoseverin, a microtubule-binding molecule with novel cellular effects
- G. R. Rosania, Y.-T. Chang, O. Perez, D. Sutherlin, H. Dong, D. J. Lockhart, P. G. Schultz, Nat. Biotechnol. 2000, 18, 304
2)A single-cell analysis of myogenic dedifferentiation induced by small molecules
- A. Duckmanton, A. Kumar, Y.-T. Chang, J. P. Brockes, Chem. Biol. 2005, 12, 1117.
3)Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors
- O. D. Perez, Y.-T. Chang, G. Rosania, D. Sutherlin, P. G. Schultz, Chem. Biol. 2002, 9, 475.

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