Sonic Hedgehog Inhibitor

No.162(July 2014)

J0009: Jervine (1)

Hedgehog (Hh) proteins control cell growth, survival, and fate, and play important roles in vertebrate body plans.¹⁾ Mutations in the Hh gene were identified by Nüsslein-Volhard and Wieschaus.²⁾ The origin of the name “Hedgehog” derives from the short and “spiked” cuticle phenotype of the Hh mutant Drosophila larvae.¹⁾ Three types of subgroups of Hh genes, Desert Hedgehog (Dhh), Indian Hedgehog (Ihh), and Sonic Hedgehog (Shh) have been identified.³⁾

Control of the Hh signal is required for conversion of ES calls to pancreatic hormone-releasing endocrine cells.⁴⁾ Activation of Shh signaling, in combination with Oct4, reprograms mouse embryonic and adult fibroblasts into iPS cells.⁵⁾

It has been reported that Jervine (1) blocks Shh signal pathway and exposure of chick embryos to 1 results in cyclopia.⁶⁾

References

1)Hedgehog: Functions and mechanisms
- M. Varjosalo, J. Taipale, Genes Dev. 2008, 22, 2454.
2)Mutations affecting segment number and polarity in Drosophila
- C. Nüsslein-Volhard, E. Wieschaus, Nature 1980, 287, 795.
3)Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
- Y. Echelard, D. J. Epstein, B. St-Jacques, L. Shen, J. Mohler, J. A. McMahon, A. P. McMahon, Cell. 1993, 75, 1417.
4)Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
- K. A. D’Amour, A. G. Bang, S. Eliazer, O. G. Kelly, A. D. Agulnick, N. G. Smart, M. A. Moorman, E. Kroon, M. K. Carpenter, E. E. Baetge, Nat. Biotechnol. 2006, 24, 1392.
5)Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1
- J.-H. Moon, J. S. Heo, J. S. Kim, E. K. Jun, J. H. Lee, A. Kim, J. Kim, K. Y. Whang, Y.-K. Kang, S. Yeo, H.-J. Lim, D. W. Han, D.-W. Kim, S. Oh, B. S. Yoon, H. R. Schöler, S. You, Cell Res. 2011, 21, 1305.
6)Teratogen-mediated inhibition of target tissue response to Shh signaling
- M. K. Cooper, J. A. Porter, K. E. Young, P. A. Beachy, Science 1998, 280, 1603.

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Sonic Hedgehog Inhibitor

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