Chemiluminescence Enhancer

No.155(November 2012)

B3910: 4-Bromophenol [for Biochemical Research] (1)
I0840: 4-Iodophenol [for Biochemical Research] (2)

In research for life-science, one of the frequently used chemiluminescence (CL) reagents is luminol. Luminol reacts with hydrogen peroxide in the presence of a catalyst, for example, enzymes, metals such as iron, or metal-complexes to emit strong light. In the case of luminol, blue light with a wavelength of 460 nm is emitted.

Since Thorpe et al. reported that phenolic compounds such as 4-iodophenol enhance CL by a peroxidase-luminol-hydrogen peroxide reaction,¹⁾ many improved methods have been reported and are called enhanced chemiluminescence (ECL). ECL is one of the sensitive and rapid detection methods in medical and analytical biochemistry.^2,3)

References

1)Phenols as enhancers of the chemiluminescent horseradish peroxidase-luminol-hydrogen peroxide reaction: application in luminescence-monitored enzyme immunoassays
- H. G. Thorpe et al., Clin. Chem. 1985, 31, 1335.
2)Chemiluminescent and bioluminescent methods in analytical chemistry
- L. J. Kricka, G. H. G. Thorpe, Analyst 1983, 108, 1274.
3)Enhanced chemiluminescence enzyme immunoassay
- L. J. Kricka et al., Pure & Appl. Chem. 1987, 59, 651.
4)p-Iodophenol-enhanced luminol chemiluminescent assay applied to discrimination between acute lymphoblastic and minimally differentiated acute myeloid (FAB-M0) or acute megakaryoblastic (FAB-M7) leukemias
- M. Costa et al., Hematol. J. 2004, 5, 496.

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