Pinostilbene (Antioxidant)

No.154(November 2014)

P1927: Pinostilbene (1)

Resveratrol is a stilbenoid which was isolated from Veratrum grandiflorum Loes Fil.* in 1940¹⁾ and has broad spectrum effects including anti-infective, anti-oxidant, and cardioprotective functions.²⁾

It has been reported that pinostilbene (3,4′-dihydroxy-5-methoxy-trans-stilbene, 1), one of the methylated resveratrol derivatives, has many biological activities. Some of the activities are regarding cell proliferation, algicidal, antiplasmodial, and cyclooxygenase inhibition activity.^3-5) TCI provides the product line of stilbenoid derivatives.

*cf. Veratrum album

References

1)The phenolic substances of white hellebore (Veratrum grandiflorum Loes. Fil.) V
- M. Takaoka, J. Faculty Sci. Hokkaido Imperial University, Ser. III, 1940, 3, 1.
2)Therapeutic potential of resveratrol: The in vivo evidence
- J. A. Baur, D. A. Sinclair, Nat. Rev. Drug Discov. 2006, 5, 493.
3)In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer
- S. Paul, C. S. Mizuno, H. J. Lee, X. Zheng, S. Chajkowisk, J. M. Rimoldi, A. Conney, N. Suh, A. M. Rimando, Eur. J. Med. Chem. 2010, 45, 3702.
4)Algicidal activity of stilbene analogues
- C. S. Mizuno, K. K. Schrader, A. M. Rimando, J. Agric. Food Chem. 2008, 56, 9140.
5)A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds
- J. Bajsa, K. Singh, D, Nanayakkara, S. O. Duke, A. M. Rimando, A. Evidente, B. L. Tekwani, Biol. Pharm. Bull. 2007, 30, 1740.

Related Compounds

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Pinostilbene (Antioxidant)

References

Related Compounds

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