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Safe and Easy-to-handle Trifluoromethoxylating Agent: TFNf

Advantages

  • Safe, easy-to-handle and stable liquid
  • A practical generator of active CF3O anion species
  • Enables trifluoromethoxylation of electrophilic substrates; alkyl halides and triflates, unsaturated and aromatic compounds
  • Useful for synthesis of biologically active compounds and drug discovery studies

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Applications

Trifluoromethoxylation of secondary alcoholic hydroxyl groups

Trifluoromethoxylation of alkyne moiety


In the above reactions, first T4150 reacted with AgF to generate an active CF3O anion species.

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References

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