寡核苷酸硫代磷酸酯合成用的硫代转移试剂

DNA和RNA上的硫代磷酸酯由于其核酸酶的抗药性，通过抗转录作用机理成为新的治疗药物，从而引起了人们的关注¹⁾。Beaucage 试剂 (1)²⁾，双(苯乙酰)二硫化物 (2)³⁾和苍耳烷氢化物 (3)^4,5)广泛地被用作硫代转移试剂，并用亚磷酰胺法来合成寡核苷酸硫代磷酸酯。另外，3的优点在于它不产生导致副反应和有毒物质的氧化物质这样的副产物，如二硫化碳或氰胺。

B3125,B3623,X0001

关键词:
B3125 Beaucage 试剂 [66304-01-6]
B3623 双(苯乙酰)二硫化物 [15088-78-5]
X0001 苍耳烷氢化物 [6846-35-1]

文献

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寡核苷酸硫代磷酸酯合成用的硫代转移试剂

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