text.skipToContent text.skipToNavigation

我的账户

订单

快速订购表

报价单

保存的购物车

导入购物车

账户详情

退出
登录
- 登录
- 注册
¥0.00

- 登录
- 注册

轻松扫码查看产品文档 | TCIMAIL No.197 已上新 | TCI试剂——品质可靠，值得信赖
订购方法？联系方式：021-67121386 / Sales-CN@TCIchemicals.com

Maximum quantity allowed is 999

请选择数量

产品 > TCI热门产品信息 > TCI热门产品信息 2017 >

抑制癌症干细胞的抗肿瘤植物化学成分

具有生物活性的呋喃并萘醌napabucasin最早发现于Tabebuia cassinoides的树皮中¹⁾。据报道，napabucasin对KB细胞及各种癌细胞株具有显著的细胞毒性^1-4)。此外，napabucasin通过抑制STAT3(信号转导和转录激活因子3)对基因转录的驱动作用，可以杀死从多种癌组织中分离出的癌症干细胞。在小鼠模型中，napabucasin有效抑制了癌症的复发和转移，因此，有望用于癌症疗法的开发中⁵⁾。

A3110

关键词:

A3110 2-乙酰基萘并[2,3-b]呋喃-4,9-二酮 [83280-65-3]

文献

1) Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides
- M. M. Rao, D. G. I. Kingston, J. Nat. Prod. 1982, 45, 600.
2) Furanonaphthoquinone Analogs Possessing Selectivity in Antitumor Activity Compared to Normal Cells
- K. Hirai, J. Koyama, J. Pan, E. Shimamura, H. Shimada, T. Yamori, S. Sato, K. Tagahara, T. Tsuruo, Cancer Detect. Prev. 1999, 23, 539.
3) Cytotoxic activity toward KB cells of 2-substituted naphtho[2,3-b]furan-4,9-diones and their related compounds
- M. Ogawa, J. Koyanagi, A. Sugaya, Aiko, T. Tsuda, H. Ohguchi, K. Nakayama, K. Yamamoto, A. Tanaka, Biosci. Biotechnol. Biochem. 2006, 70, 1009.
4) Anticancer Activities of Six Selected Natural Compounds of Some Cameroonian Medicinal Plants
- V. Kuete, H. K. Wabo, K. O. Eyong, M. T. Feussi, B. Wiench, Be. Krusche, P. Tane, G. N. Folefoc, T. Efferth, PLOS ONE 2011, 6, e21762.
5) Suppression of cancer relapse and metastasis by inhibiting cancer stemness
- Y. Li, H. A. Rogoff, S. Keates, Y. Gao, S. Murikipudi, K. Mikule, D. Leggett, W. Li, A. B. Pardee, C. J. Li, PNAS 2015, 112, 1839.