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抗酒精中毒研究中的乙醛脱氢酶抑制剂
Disulfiram (又名:tetraethylthiuram disulfide)开发于19世纪1),它被用作橡胶硫化有机促进剂2,3)。Disulfiram可以作为活性自由基聚合添加剂4,5),Ca2+-ATP酶激活剂6),V-ATP酶激活剂7)等。E. Jacobsen等人发现了它。1948年,disulfiram被吸收到体内抑制乙醇代谢过程中的乙醛脱氢酶,防止乙醛在体内聚集而引发急性症状。因此disulfiram对酒精中毒有抑制效应。
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