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一种存在于冬虫夏草菌丝中的抗菌物质
冬虫夏草是一种寄生在昆虫体内的菌类。其菌丝从蝙蝠蛾科的昆虫幼虫中发芽,蛹虫草寄生于鳞赤目幼虫中,可用于传统中药中。一种存在于冬虫夏草中的生物活性物质—Cordycepin(—cordycepin hydrate)(1),化学结构与腺苷相似。由于对RNA聚腺苷的酸化反应等3-6)具有抑制活性,因此1呈现出抗肿瘤功效。此外,也有报道称1具有杀虫7)和抗菌8)的功效。
文献
- 1)Pharmacological actions of Cordyceps, a prized folk medicine
- 2)Cordyceps fungi: natural products, pharmacological functions and developmental products
- 3)Antitumour activity of cordycepin in mice
- 4)Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation
- 5)The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line
- 6)RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells
- 7)Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris
- 8)Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp.