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CAS RN: 67-03-8 | 产品编码: T0181
Thiamine Hydrochloride
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* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
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* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
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技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Argentometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Solubility in Water | almost transparency |
| Water | max. 5.0 % |
物性（参考值）
GHS
| 信号词 | 警告 |
| 危险性说明 | H303 : 吞咽可能有害。 |
| 防范说明 | P312 : 如感觉不适，呼叫急救中心/医生。 |
相关法规
| RTECS# | XI7350000 |
运输信息
| 监管条件代码(*) |
应用
Thiamine (Vitamin B1): One of Essential B Vitamins with Many Important Functions in All Tissues
Thiamine, also known as vitamin B1, is one of essential B vitamins that has many important functions in all tissues.1-3) Two types of water soluble thiamine salts, thiamine hydrochloride [T0181] and thiamine nitrate [T0182], are commonly used to products.4) Thiamine pyrophosphate (diphosphate) chloride [T0183] is the biologically active form of thiamine. In addition, thiamine hydrochloride is also used as an efficient catalyst for chemical reactions.7,8) For your reference, [A2633] is a key synthetic intermediate of thiamin. (The product is for research purpose only.)
References
- 1) Thiamin biosynthesis in prokaryotes (a review)
- 2) Molecular mechanisms of thiamine utilization (a review)
- 3) The structural and biochemical foundations of thiamin biosynthesis (a review)
- 4) Chemical stability and reaction kinetics of two thiamine salts (thiamine mononitrate and thiamine chloride hydrochloride) in solution
- 5) Analytical profile of thiamin hydrochloride (a review of the preparation, physical properties, metabolism, methods of determination, etc., of thiamin)
- 6) Determination of thiamine by high-performance liquid chromatography
- 7) Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols
- 8) Thiamine hydrochloride (VB1): an efficient promoter for the one-pot synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in water medium
应用
Synthesis of Formamide Derivatives Catalyzed by Vitamin B1 Hydrochloride
N-Formination of aniline using VB1 as a catalyst:
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
A mixture of aniline (5 mmol), formic acid (1 mL), and VB1 (0.1 mmol, 2 mol%) is heated at 80 °C under stirring for 10 minutes. After completion of the reaction as indicated by TLC, 20 mL of EtOAc is added and washed with 5% HCl aq., 5% Na2CO3 aq., and brine. Then, the organic layer is dried over MgSO4 and concentrated to afford N-formylaniline in 96% yield without further purification.
References
- A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst
应用
Thiamine Catalyzed Benzoin Condensation: Synthesis of Fluorobenzoins
Typical procedure : Synthesis of 4,4’-Difluorobenzoin
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
1,2-Bis(4-fluorophenyl)-2-hydroxyethanone is synthesized by condensation of 4-fluorobenzaldehyde (5.0 g, 40 mmol) in the presence of thiamine hydrochloride (0.67 g, 2.0 mmol) and sodium hydroxide (0.20 g, 5.0 mmol) in ethanol. The reaction is carried out at 50°C for 48 h and then the mixture is cooling on ice. A formed crude product is filtered and washed with ice cold 75% ethanol. The material is recrystallized from ethanol to give white crystals in 75% yield.
References
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