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CAS RN: 22189-32-8 | 产品编码: S0584
Spectinomycin Dihydrochloride Pentahydrate
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* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
| 产品编码 | S0584 |
| 纯度/分析方法 | >98.0%(T)(N) |
| 分子式/分子量 | C__1__4H__2__4N__2O__7·2HCl·5H__2O = 495.35 |
| 外观与形状（20°C） | 固体 |
| 储存温度 | 冷藏 (0-10°C) |
| 应避免的情况 | 加热 |
| CAS RN | 22189-32-8 |
| 相关CAS RN | 21736-83-4&1695-77-8 |
| PubChem物质ID | 354335325 |
| Merck Index (14) | 8739 |
| MDL编号 | MFCD00150886 |
技术规格
| Appearance | White to Almost white powder to crystal |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 98.0 % |
| Specific rotation [a]20/D | +15.0 to +21.0 deg(C=1,H2O) |
| Water | 16.0 to 20.0 % |
| NMR | confirm to structure |
物性（参考值）
| 熔点 | 207 °C(dec.) |
| 比旋光度 [α]D | 15° (C=1,H2O) |
| 溶解性（不溶于） | 乙醇 |
GHS
相关法规
| RTECS# | WG7400000 |
| 新化学物质备案回执号 | B1A232215694 |
运输信息
| 监管条件代码(*) | Q类 （糖类，生物碱类，抗生素类，激素类） |
应用
Spectinomycin Dihydrochloride: An Aminocyclitol Antibiotic Used for the Treatment of Infection with Streptomyces spectabilis and for Molecular Cloning
Spectinomycin dihydrochloride is an aminoglycoside antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. Spectinomycin exerts its bactericidal activity by inhibiting protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. Spectinomycin is highly effective for the treatment of infections with Neisseria gonorrhoeae. In vitro studies have shown no cross-resistance of Neisseria gonorrhoeae between spectinomycin hydrochloride and benzylpenicillins [A2092] [P1770] [P1772]. On bioscience research, a resistance-conferring gene for spectinomycin can also be used as a selection marker in bacteria for molecular cloning purposes. In addition, spectinomycin is used as a selection agent for transformed plant cells that contain the selectable marker gene SpcR. (The product is for research purpose only.)
References
- Spectinomycin (a review on the structure, antibacterial activity, and mechanisms of resistance of spectinomycin)
- Chemistry of spectinomycin: its total synthesis, stereocontrolled rearrangement, and analogs
- Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
- Human safety and genetically modified plants: a review of antibiotic resistance markers and future transformation selection technologies
- Plastid transformation in flowering plants (a review)
- Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement (a review)
- Determination of spectinomycin hydrochloride and its related substances by HPLC-ELSD and HPLC-MSn
- Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations
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