Rapamycin

References

• Regulation of bone formation using rapamycin-induced BMP2 expression system: influence of implanted cell number　
  • D.-J. Lim, B.K. Park, W.G. Jang, K.-N. Lee, R. Franceschi, S.-H. Kim, S.-E. Lee, J.-T. Koh, Mol. Cell. Toxicol. 2010, 6, 187.
• Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway
  • K.-W. Lee, J.-Y. Yook, M.-Y. Son, M.-J. Kim, D.-B. Koo, Y.-M. Han, Y.S. Cho, Stem Cells Dev. 2010, 19, 557.
• Use of a Stringent Dimerizer-Regulated Gene Expression System for Controlled BMP2 Delivery
  • J.-T. Koh, C. Ge, M. Zhao, Z. Wang, P. H. Krebsbach, Z. Zhao, R.T. Franceschi, Mol. Ther. 2006, 14, 684.

References

• Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition
  • C. Zhang, C. Huang, H. Xia, H. Xu, Q. Tang, F. Bi, Cell Death Dis. 2022, 13, 615.
• Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice
  • S. Ozcelik et al., PLoS ONE 2013, 8, e62459.
• Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease
  • A.-L. Lin et al., J. Cereb. Blood Flow Metab. 2013, 33, 1412.

References

• 1) Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
• C.X. Wang, B.D. Sather, X. Wang, J. Adair, I. Khan, S. Singh, S. Lang, A. Adams, G. Curinga, H.-P. Kiem, C. H. Miao, D.J. Rawlings, B.E. Torbett, Blood 2014, 124, 913.
• 2) Assessing the impact of cyclosporin A on lentiviral transduction and preservation of human hematopoietic stem cells in clinically relevant ex vivo gene therapy settings
• C. Petrillo, A. Calabria, F. Piras, A. Capotondo, G. Spinozzi, I. Cuccovillo, F. Benedicenti, L. Naldini, E. Montini, A. Biffi, B. Gentner, A. Kajaste-Rudnitski, Hum. Gene Ther. 2019, 30, 1133.

References

• mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
  • D.-H. Kim, D. D. Sarbassov, S. M. Ali, J. E. King, R. R. Latek, H. Erdjument-Bromage, P. Tempst, D. M. Sabatini, Cell 2002, 110, 163.
• Defining the role of mTOR in cancer
  • D. A. Guertin, D. M. Sabatini, Cancer Cell 2007, 12, 9.
• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
  • B. Ravikumar, C. Vacher, Z. Berger, J. E. Davies, S. Luo, L. G. Oroz, F. Scaravilli, D. F. Easton, R. Duden, C. J. O'Kane, D. C. Rubinsztein, Nat. Genet. 2004, 36, 585.
• Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
  • D. D. Sarbassov, S. M. Ali1, S. Sengupta, J.-H. Sheen, P. P. Hsu, A. F. Bagley, A. L. Markhard, D. M. Sabatini, Mol. Cell 2006, 22, 159.
• mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
  • K. E. O'Reilly, F. Rojo, Q.-B. She, D. Solit, G. B. Mills, D. Smith, H. Lane, F. Hofmann, D. J. Hicklin, D. L. Ludwig, J. Baselga, N. Rosen, Cancer Res. 2006, 66, 1500.