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CAS RN: 3650-09-7 | 产品编码: C2488
Carnosic Acid (Synthetic)
×
纯度/分析方法: >97.0%(T)(HPLC)
别名：
- 鼠尾草酸 (合成)
- (4aR,10aS)-5,6-二羟基-7-异丙基-1,1-二甲基-1,2,3,4,4a,9,10,10a-八氢菲-4a-羧酸 (合成)
- (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid (Synthetic)
产品文档：
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* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
* 无具体发货日期的情况，如：显示“8个工作日后发货”，将在您订购日起的8个工作日后发货。
* 我们将以最优方式从上海/天津两大仓库发货。国内库存不足，需两周左右向日本总部调货。
* 对于可分装产品，11:30前的订单，当天发货；11:30后的订单，隔天发货。
* 如需大包装，请点击“大包装询价”按钮（对于某些产品我们无法提供大包装）。
* TCI会经常复审储藏条件以对其进行优化，请以在线目录为准，敬请留意。
* 更多信息，请联系营业部：021-67121386 / Sales-CN@TCIchemicals.com 。任何货期、规格或包装方面的需求，请联系我们 。
技术规格
| Appearance | White to Yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| Specific rotation [a]20/D | +182 to +195 deg(C=1, MeOH) |
物性（参考值）
| 熔点 | 190 °C |
| 比旋光度 [α]D | 184° (C=1,MeOH) |
GHS
相关法规
| 新化学物质备案回执号 | B1A232216322 |
运输信息
| 监管条件代码(*) |
应用
Efflux pump research / Efflux pump inhibitor
Carnosic acid is a compound known as an abietane diterpene. According to the study using Staphylococcus aureus, carnosic acid (10 μg/ml) showed a 2-fold potentiation of tetracycline activity against XU212 (TetK possessing strain) and 8-fold potentiation of erythromycin activity against RN4220 (Msr possessing strain).1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
- 1) Antibacterial and resistance modifying activity of Rosmarinus officinalis
- Rosmarinus officinalis as an Antioxidant
- Antioxidant Activity of a Rosemary Extract and Its Constituents, Carnosic Acid, Carnosol, and Rosmarinic Acid, in Bulk Oil and Oil-in-Water Emulsion
- Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism
- Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
- Carnosic acid, a new class of lipid absorption inhibitor from sage
- 1)M. Tada, T. Ohkanda, J. Kurabe, Chem. Pharm. Bull. 2010, 58, 27.
- 2)M. Tada, PCT Int. Appl. WO 2009060547, 2009.
- 3)M. Tada, TCIMAIL 2012, number 150, 2.
应用
Notice
This product is the synthetic carnosic acid. For your reference, recent reviews on carnosic acid after 2015 are shown on anther carnosic acid [C3477] product application on the website. (The product is for research purpose only.)
应用
Antioxidant study
References
应用
Neuron protective effects study
Reference
应用
Inhibition of adipocyte differentiation study
Reference
应用
Inhibition of human 5-Lipoxigenase study
Reference
应用
Inhibition of lipid absorption study
Reference
应用
Synthesis of carnosic acid
Reference
PubMed Literature
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