RTKs (Receptor tyrosine kinases) are transmembrane glycoproteins present on cell surface that activate various kinds of main cell signaling pathways like MAPK pathway and PI3K pathway. They're important molecules in biological phenomenon to control basic cell activities such as proliferation, differentiation, survival and death. Their excess expression and active mutation have been reported in cancer cells. Numerous specific low molecular-weight drugs and antibodies designed to inhibit their activities have been developed.
