Pirfenidone (1) is a bioactive small molecule, and was first reported as an anti-inflammatory agent in the 1970s.1) Recently, Oku et al. have reported its unique anti-inflammatory properties.2) Additionally in the 1990s, Margolin et al. discovered that pirfenidone had an antifibrotic action.3) Here, they showed that pirfenidone was an inhibitor of collagen production and fibroblast proliferation in the lungs of rats and hamsters. The study of antifibrotic activity in various organs has been developed by using a variety of animal models.4)
This product is for research purpose only.
Published TCIMAIL newest issue No.197
