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Published TCIMAIL newest issue No.197
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We have line-up of hydroxypropyl methylcellulose (HPMC) encapsulated reagents for condensation reactions1,2) according to popular demand. In addition to the existing encapsulated reagent of EDC·HCl/HOBt·H2O (Product No. R0274), we have encapsulated reagent of DMTMM (Product No. R0294), encapsulated reagent of HATU (Product No. R0295) and encapsulated reagent of HOTU (Product No. R0297) as uronium condensing agents, and encapsulated reagent of phosphonium condensing agent (Product No. R0296). These are useful in various situation such as reaction screening and compound library construction.
We have provided procedures of reactions using these products on each product pages, so please refer to them when carrying out reactions and processing.
Products
- R0274
- Reagents for Condensation Reactions (EDCI·HCl, HOBt·H2O) (HPMC encapsulated)
- R0294
- Reagents for Condensation Reactions (DMT-MM) (HPMC encapsulated)
- R0295
- Reagents for Condensation Reactions (HATU) (HPMC encapsulated)
- R0296
- Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)
- R0297
- Reagents for Condensation Reactions (HOTU) (HPMC encapsulated)
Advantages
- Capsule has an outer diameter of 5 mm and a length of 14 mm and contains a preweighed amount of catalyst or reagent.
- Capsules dissolve in the reaction solution, therefore adding capsules makes it simple to carry out reactions.
- Dissolves in water, DMSO, DMF, NMP, DMAc, THF/water and dioxane/water. 1)
Application
Condensation Reaction with R0274
You can see more information on the "Applications" tab of product detail page.
Related Products
- D1601
- EDCI·HCl
- H0468
- HOBt Monohydrate (= HOBt·H2O)
- D2919
- DMTMM
- A1797
- HATU
- B1774
- 1H-Benzotriazol-1-yloxy-tripyrrolidinophosphonium Hexafluorophosphate
- E1306
- HOTU
- R0273
- Reagents for Metallophotoredox Cross-Coupling Reactions [NiBr2(dme), [Ir[dF(CF3)ppy]2(dtbbpy)]PF6, DABCO] (HPMC encapsulated)
- R0275
- Reagents for Suzuki-Miyaura Cross-Coupling Reactions [Pd(dppf)Cl2·CH2Cl2, Cs2CO3] (HPMC encapsulated)
- B5417
- Bis(1,5-cyclooctadiene)nickel(0) (Wax encapsulated) (ca. 0.05mmol/capsule)
References
- 1) Reagent and Catalyst Capsules: A Chemical Delivery System for Reaction Screening and Parallel Synthesis
- 2) HPMC: A Biomass-Based Semisynthetic Sustainable Additive Enabling Clean and Fast Chemistry in Water
- 3) Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water
