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Published TCIMAIL newest issue No.197
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Reagent for Primary Sulfonamide Synthesis
tBuONSO (1) is utilized as a reagent for primary sulfonamide synthesis. 1 reacts with Grignard reagents or organolithium reagents to give sulfonamides via nucleophilic attack on the sulfur atom of 1 and successive elimination of isobutene. Organometallic reagents with various carbon skeletons such as aryl, heteroaryl, cyclopropyl, even sterically hindered isopropyl and tert-butyl groups are applicable.
Related Products
- U0150
- (tert-Butoxyimino)-λ4-sulfanone (= tBuONSO)
- B3960
- Bis(sulfur Dioxide)-1,4-diazabicyclo[2.2.2]octane Adduct (= DABSO)
- U0113
- Sulfur Dioxide 1-Methylpyrrolidine Adduct (= TIMSO)
- T3773
- (Triphenylmethyl)thionyl Imide (= TrNSO)
References
- 1) Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO
- 2) Direct one step dehydrogenative C-H sulfonimidation of unfunctionalized arenes: A conveneient protocol to emerging medicinal chemistry motifs without prefunctionalized arenes
