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CAS RN: 609799-22-6 | Product Number: T3813
Tasimelteon
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Purity: >98.0%(HPLC)
Synonyms:
- N-[[(1R,2R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
58,00 €
|
Contact Us | 7 |
|
| 50MG |
223,00 €
|
Contact Us | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3813 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__9NO__2 = 245.32 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 609799-22-6 |
| Reaxys Registry Number | 15439325 |
| PubChem Substance ID | 468592958 |
| MDL Number | MFCD09033789 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 5.30 to 6.10 % |
| Specific rotation [a]20/D | -41.0 to -46.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 78 °C |
| Specific Rotation | -45° (C=1,CHCl3) |
GHS
Related Laws:
| RTECS# | TX1450577 |
Transport Information:
| HS Number | 2932990090 |
Application
Tasimelteon: A Selective Melatonin MT1 and MT2 Receptors Agonist
Tasimelteon (BMS-214778) is a melatonin [M1105] receptor agonist with both high affinity for melatonin MT1 and MT2 receptors, similar to other members of the melatonin receptor agonist including ramelteon [R0216] and agomelatine [A2606]. Characteristically, tasimelteon exhibits a greater affinity for the MT2 as compared to the MT1 receptor. The agonist activity at the MT1 and MT2 receptors has been reported to contribute to its sleep-promoting properties. And then, tasimelteon currently is approved in the United States and the EU for the treatment of the treatment of non-24-hour sleep-wake disorder. (The product is for research purpose only.)
References
- Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist
- Tasimelteon, a melatonin agonist for the treatment of insomnia and circadian rhythm sleep disorders (a review)
- Tasimelteon: a selective and unique receptor binding profile
- Tasimelteon: first global approval (a review)
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