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Published TCIMAIL newest issue No.197
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CAS RN: 174671-46-6 | Product Number: T3775
Tavaborole
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Purity: >98.0%(HPLC)
Synonyms:
- 5-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol
- AN-2690
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
89,00 €
|
1 | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3775 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__7H__6BFO__2 = 151.93 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic,Heat Sensitive |
| CAS RN | 174671-46-6 |
| Reaxys Registry Number | 10657796 |
| PubChem Substance ID | 468592937 |
| MDL Number | MFCD10699483 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 130.0 to 134.0 °C |
Properties (reference)
| Melting Point | 132 °C |
| Degree of solubility in water | 6,029 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| HS Number | 2934999090 |
Application
Tavaborole: A Boron-Containing Antifungal Agent with Aminoacyl-tRNA Synthetase Inhibiting Action
Tavaborole (AN-2690) is a boron-containing antifungal agent with a unique mechanism of action. It is reported that tavaborole inhibits fungal protein synthesis by inhibition of an aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS), which catalyze the attachment of the correct amino acid to its corresponding tRNA during translation of the genetic code. Tavaborole approved by FDA for the treatment of onychomycosis in 2014. (The product is for research purpose only.)
References
- Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis
- An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site
- Aminoacyl-tRNA synthetase inhibitors as antimicrobial agents: a patent review from 2006 till present
- Tavaborole: First Global Approval
- Development and validation of an HPLC-UV method to quantify tavaborole during in vitro transungual permeation studies
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