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CAS RN: 322-79-2 | Product Number: T3601
Triflusal
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Purity: >98.0%(T)
Synonyms:
- Acetyl-4-(trifluoromethyl)salicylic Acid
- 2-Acetoxy-4-(trifluoromethyl)benzoic Acid
- Drisgen
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€232.00
|
1 | 1 |
|
| 1G |
€648.00
|
1 | 6 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3601 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__7F__3O__4 = 248.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 322-79-2 |
| Reaxys Registry Number | 2945374 |
| PubChem Substance ID | 354335089 |
| Merck Index (14) | 9688 |
| MDL Number | MFCD00866793 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 96.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 113.0 to 117.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 115 °C |
| Maximum Absorption Wavelength | 297(H2O) nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 206-297-5 |
Transport Information:
| HS Number | 2918290090 |
Application
Triflusal: An Antiplatelet Aggregation Agent
Triflusal is an antiplatelet aggregation agent having a trifluoromethyl group at the 4-position. It is metabolized to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) which inhibits cyclogxygenase-1 (COX-1) in platelets. Furthermore, both triflusal and HTB are also able to increase cyclic adenosine monophosphate (cAMP) [A2381] levels in platelets through inhibition of platelet phosphodiesterases which regulate intracellular cAMP levels. Moreover, triflusal enhances the production of NO by neutrophils via stimulation of the constitutive activity of nitric oxide (NO) synthase (cNOS). It is considered that triflusal shows the antiplatelet aggregation activity by these actions. (The product is for research purpose only.)
References
- Triflusal: An Old Drug in Modern Antiplatelet Therapy. Review of Its Action, Use, Safety and Effectiveness
- Determination of triflusal in human plasma by high performance liquid chromatography with automated column switching system
- Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography
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