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Published TCIMAIL newest issue No.197
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CAS RN: 8025-81-8 | Product Number: S0575
Spiramycin
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Purity: >90.0%(HPLC)
Synonyms:
- Formacidine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
97,00 €
|
1 | 9 |
|
| 25G |
311,00 €
|
1 | 3 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0575 |
| Purity / Analysis Method | >90.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__3H__7__4N__2O__1__4 = 843.07 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 8025-81-8 |
| Reaxys Registry Number | 8196846 |
| PubChem Substance ID | 87560536 |
| Merck Index (14) | 8752 |
| MDL Number | MFCD01314545 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 90.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 %(calcd.on dried substance) |
| Specific rotation [a]20/D | -77.0 to -85.0 deg(C=2, AcOH(10%))(after drying) |
| Drying loss | max. 4.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
| Specific Rotation | -81° (C=2,AcOH(10%)) |
GHS
Related Laws:
| EC Number | 232-429-6 |
| RTECS# | WG9400000 |
Transport Information:
| HS Number | 2941900000 |
Application
Spiramycin: A 16-Membered Macrolide Substance Having Antibacterial Activity
Macrolide antibiotics are classified by the size of the macrocyclic lactone ring of aglycone as 14-, 15- or 16-membered ring macrolides. Macrolides are characterized by similar chemical structures, mechanisms of action and resistance, but vary in the different pharmacokinetic parameters, and spectrum of activity. Spiramycin is a 16-membered macrolide substance having antibacterial activity isolated from the growth of Streptomyces ambofaciens. The antibacterial spectrum of spiramaycin is quite broad from Gram-positive and Gram-negative bacteria to Toxoplasma gondii, a parasitic protist. Spiramycin inhibits protein synthesis by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry.
References
- Mechanism of action of spiramycin and other macrolides (a review)
- Activity of spiramycin against Toxoplasma gondii in vitro, in experimental infections and in human infection (a review)
- Pharmacodynamics and pharmacokinetics of spiramycin and their clinical significance
- Spiramycin renaissance
- Analysis of macrolide antibiotics (a review)
PubMed Literature
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