Maintenance Notice (4:30 AM - 11:00 AM December 21, 2024): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 24057-28-1 | Product Number: P0942
Pyridinium p-Toluenesulfonate
×
![]()
×
Purity: >98.0%(T)
Synonyms:
- PPTS
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€29.00
|
7 | ≥60 |
|
| 100G |
€79.00
|
3 | 18 |
|
| 500G |
€252.00
|
12 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | P0942 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__5H__5N·C__7H__8O__3S = 251.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic |
| CAS RN | 24057-28-1 |
| Reaxys Registry Number | 3764305 |
| PubChem Substance ID | 87575059 |
| MDL Number | MFCD00013108 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 118.0 to 122.0 °C |
| Solubility in Water | almost transparency |
Properties (reference)
| Melting Point | 120 °C |
| Solubility in water | Soluble |
| Solubility (soluble in) | Ethanol, Chloroform, dichloromethane, Acetone |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
Related Laws:
| EC Number | 246-002-7 |
Transport Information:
| HS Number | 2933310000 |
Application
Application for Introduction of Protecting Groups Using PPTS as an Acid Catalyst
Typical procedure :PPTS catalyzed THP protection of (R)-(+)-glycidol
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
Pyridinium p-toluenesulfonate (PPTS) (1.00 g, 4.05 mmol) and 3,4-dihydro-2H-pyran (11.3 mL, 121.5 mmol) are added to a stirred solution of (R)-(+)-glycidol (6.00 g, 80.99 mmol) in dichloromethane (80 mL) at 0 °C under argon atmosphere. After 6 h, aqueous NaHCO3 solution (60 mL) is added and the layers are separated. The aqueous layer is extracted with dichloromethane (3x50 mL). Combined organic layer is dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by column chromatography (EtOAc:hexane = 1:5) to give the desired product (9.22 g, 72%).
References
- A Facile Synthesis of (S)-Felodipine
Application
PPTS Catalyzed Hydrolysis of Dioxolane-type Acetals
Reference
- Pyridinium Tosylate, A Mild Catalyst for Formation and Cleavage of Dioxolane-type Acetals
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.