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CAS RN: 1360614-48-7 | Product Number: N1201
Necrosulfonamide
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Purity: >95.0%(HPLC)
Synonyms:
- (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)acrylamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25MG |
€185.00
|
Contact Us | 16 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | N1201 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__5N__5O__6S__2 = 461.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 1360614-48-7 |
| Reaxys Registry Number | 25249079 |
| PubChem Substance ID | 468592510 |
| MDL Number | MFCD02370191 |
Specifications
| Appearance | Yellow to Brown to Dark green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 257 °C(dec.) |
GHS
Related Laws:
Transport Information:
| HS Number | 2935909099 |
Application
Necrosulfonamide: A Very Specific and Potent Necrosis Inhibitor
Necrosulfonamide is a very specific and potent necrosis inhibitor. It specifically blocks necrosis signaling downstream of the receptor-interacting serine-threonine kinase 3 (RIP3) activation.
References
- Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
- Dissecting Programmed Cell Death with Small Molecules (a review)
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